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. Author manuscript; available in PMC: 2019 Feb 11.
Published in final edited form as: Mutat Res. 2006 Sep 28;602(1-2):83–91. doi: 10.1016/j.mrfmmm.2006.08.004

Table 2.

Total DNA adducts and cII mutant frequency in liver and kidney of rats treated with different doses of aristolochic acid

Aristolochic
acid (mg/kg)		 Total DNA adducts
(×10−8 nucleotides)a,b
 Mutant frequency
(×10−6)a,c
Liver Kidney Liver Kidney
 0   0   0 28 ± 6 29 ± 6
 0.1 25 ± 8  95 ± 21 37 ± 8  78 ± 21
 1.0 199 ± 75  705 ± 153 113 ± 16  242 ± 104
10.0 1967 ± 468 4598 ± 148  666 ± 173 1319 ± 360
a

The data represent the mean ± S.D. per for each group of six rats.

b

The data for total DNA adducts are taken from Table 1.

c

The data for kidney mutant frequency are from [19].