Fig. 4.

CQ (100 nM) clearly stains Aβ plaques in the AD brain tissue while NFTs of tau corresponding to Tau pathology were not detected. In a field with many neurofibrillary tangles stained by PHF1, the serial section stained with CQ compound does not reveal the NFTs (A and C). Some NFTs may be seen at near background level, but do not fluoresce at nearly the same intensity as Aβ plaques. Further, in specific taupathy, progressive supranuclear palsy (PSP) samples, the tau-positive PSP tangles in the brainstem are not detected by CQ (A-D). *marking landmark vessels.