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. Author manuscript; available in PMC: 2019 May 12.
Published in final edited form as: Nature. 2018 Nov 12;565(7737):49–55. doi: 10.1038/s41586-018-0736-4

Extended Data Figure 7. Long-range regulation of the AAA-ATPase by the lid-base interactions.

Extended Data Figure 7.

(a) and (b) The long-range association of the Rpn1-Rpn2 through a looping structure from Rpn2 (residue 820-871) observed in state ED1 (a) and ED2 (b). (c) Comparison of the Rpn1-Rpn2 long-range association between the two states shows a marked movement of 12 Å. (d) The comparison of the Rpt4-Rpt5 CC interactions with Rpn9 and Rpn10 in states EC1,2 and ED1,3. (e) Closeup views of the Rpt4-Rpt5 CC contacts with Rpn9 in states EC1,2 and ED1, and its contact switching to Rpn10 in state ED2.