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. Author manuscript; available in PMC: 2019 May 12.
Published in final edited form as: Nature. 2018 Nov 12;565(7737):49–55. doi: 10.1038/s41586-018-0736-4

Figure 6. Model of the complete cycle of substrate processing by the human 26S proteasome.

Figure 6.

The cartoon summarizes the concept of three principal modes of coordinated ATP hydrolysis observed in the seven states and our proposal of how they regulate the complete cycle of substrate processing by the proteasome holoenzyme.