Table 6. Pearson correlation coefficients (r) between gains in MPO and baseline muscle metabolites levels in TIMES.
| Skeletal muscle metabolites# | ET (n = 29) | HIIT (n = 28) | ||
|---|---|---|---|---|
| ∆ MPO | ∆ MPO | |||
| Alcohols and polyols | ||||
| Ethyleneglycol | 0.19 | -0.06 | ||
| Myo-Inositol | 0.24 | -0.04 | ||
| Amino acids | ||||
| Alanine | 0.40 | LT | 0.01 | |
| Anserine | 0.18 | LT | -0.24 | |
| β-Alanine | 0.20 | LT | -0.02 | |
| Glutamate | 0.40 | LT | 0.05 | |
| Glutamine | 0.34 | LT | -0.04 | |
| Glycine | 0.36 | LT | -0.08 | |
| Histidine | 0.40 | LT | -0.06 | |
| Isoleucine | 0.30 | 0.17 | ||
| Leucine | 0.13 | LT | 0.20 | |
| Phenylalanine | 0.46 | 0.00 | ||
| Proline | 0.38 | LT | 0.19 | |
| Threonine | 0.46 | LT | -0.12 | |
| Tyrosine | 0.12 | LT | 0.11 | |
| Valine | -0.12 | 0.11 | ||
| Carboxylic acids | ||||
| Acetate | 0.35 | 0.14 | ||
| Betaine | 0.07 | -0.16 | ||
| Citrate | 0.08 | -0.01 | ||
| Creatine | 0.35 | LT | 0.13 | |
| Creatinephosphate | -0.04 | LT | -0.14 | |
| Creatinine | 0.38 | 0.02 | ||
| Formate | 0.23 | LT | 0.06 | |
| Fumarate | 0.21 | 0.05 | ||
| Glutathione | 0.40 | LT | -0.25 | |
| Isobutyrate | 0.45 | LT | 0.09 | |
| Isocitrate | 0.26 | -0.29 | ||
| Maleate | 0.01 | 0.10 | ||
| Malonate | 0.19 | LT | 0.09 | |
| N,N-Dimethylglycine | 0.33 | -0.12 | ||
| N-Acetylaspartate | 0.33 | -0.20 | ||
| N-Acetylglutamine | 0.23 | -0.19 | ||
| Nicotinurate | 0.18 | 0.00 | ||
| Ornithine | 0.30 | LT | -0.19 | |
| Succinate | 0.20 | LT | 0.15 | |
| π-Methylhistidine | 0.21 | LT | 0.04 | |
| τ-Methylhistidine | -0.28 | 0.35 | LT | |
| Fatty acids | ||||
| 2-Hydroxyisocaproate | 0.34 | LT | -0.04 | |
| 3-Hydroxyisovalerate | 0.33 | LT | 0.23 | |
| O-Acetylcarnitine | 0.26 | LT | 0.12 | |
| Hydroxy acids | ||||
| Glycolate | -0.09 | -0.42 | ||
| Lactate | 0.30 | 0.04 | ||
| Imidazopyrimidines | ||||
| 3-Methylxanthine | 0.38 | -0.25 | ||
| Oxypurinol | 0.26 | LT | -0.06 | |
| Theophylline | 0.36 | -0.15 | ||
| Nucleosides and nucleotides | ||||
| ADP | 0.31 | -0.01 | ||
| AMP | 0.38 | -0.04 | ||
| ATP | 0.28 | LT | -0.03 | |
| NAD+ | 0.23 | LT | -0.16 | |
| NADP+ | 0.11 | LT | -0.23 | |
| Organic oxygen compounds | ||||
| 2-Phosphoglycerate | 0.37 | 0.15 | ||
| Glucose | 0.22 | LT | -0.19 | |
| Glycerol | 0.01 | 0.08 | ||
| Organic nitrogen compounds | ||||
| Carnitine | 0.29 | 0.02 | ||
| Choline | -0.16 | -0.12 | ||
| Dimethylamine | 0.36 | LT | 0.05 | |
| Histamine | 0.45 | LT | 0.13 | |
| Methylamine | 0.29 | LT | 0.30 | |
| N-Nitrosodimethylamine | 0.22 | -0.02 | ||
| Trimethylamine | 0.17 | LT | -0.15 | |
| Trimethylamine-N-oxide | 0.31 | LT | -0.15 | |
| Tartrate | -0.04 | 0.04 | ||
| Unclustered | ||||
| 2-Hydroxyphenylacetate | 0.36 | 0.07 | ||
| Acetamide | 0.16 | -0.30 | ||
| Carnosine | 0.11 | -0.06 | ||
| Dimethylsulfone | 0.24 | -0.24 | ||
| Niacinamide | 0.32 | -0.01 | ||
| Pyrimidine | 0.11 | LT | 0.04 | |
| Pyruvate | 0.42 | -0.18 | ||
| Taurine | 0.18 | LT | -0.03 | |
ET: Continuous endurance training; HIIT: High-intensity interval training; MPO: Maximal power output; ∆: Change pre to post intervention. LT Data log transformed before analysis. Bold values are correlation coefficients (r) ≥ 0.2.
# Metabolites chemical taxonomy was based on class and sub-class from Human Metabolome Database.