Table 3. Significant predictors of death from all-cause, liver-related death or cirrhosis development corrected for achieving sustained viral response (SVR).

Event	Predictors		Univariate		Multivariate
			HR (95% CI)	p-value	HR (95% CI)	p-value
Death from all causes	Baseline LSM
		<10kPa	Reference		Reference
		10–16.9kPa	1.33 (0.63–2.76)	0.446	1.09 (0.50–2.34)	0.835
		17-75kPa	6 (3.55–10)	<0.005	3.64 (1.65–7.9)	0.001
	Baseline lnHA		1.93 (1.59–2.36)	<0.005	1.37 (1.03–1.83)	0.031
	Baseline age		1.03 (1.01–1.06)	0.004	NS	-
	Male sex		1.66 (0.97–2.85)	0.064	NS	-
	Ever excessive alcohol use		1.6 (0.97–2.64)	0.063	NS	-
	Ever intravenous drug use		0.94 (0.55–1.62)	0.830	NS	-
	SVR		0.46 (0.19–1.15)	0.094	0.32 (1.03–1.83)	0.014
Event	Predictors		Univariate		Multivariate
			sHR (95% CI)	p-value	sHR (95% CI)	p-value
Liver-related deatha	Baseline LSM
		<10kPa	Reference		Reference
		10–16.9kPa	9.5 (0.98–91.3)	0.051	4.04 (0.41–39.8)	0.176
		17-75kPa	97 (13.2–713)	<0.005	11 (1.22–98.6)	0.018
	Baseline lnHA		5.2 (3.43–7.95)	<0.005	3.15 (1.77–5.62)	<0.005
	Baseline age		1.07 (1.03–1.11)	<0.005	NS	-
	Male sex		1.97 (0.79–4.87)	0.144	NS	-
	Ever excessive alcohol use		1.96 (0.86–4.49)	0.109	NS	-
	Ever intravenous drug use		2.1 (0.97–4.59)	0.060	NS	-
	SVR		1.09 (0.67–3.22)	0.883	0.69 (0.22–2.14)	0.523
Complicationsb	Baseline LSM
		<10kPa	Reference		Reference	0.034
		10–16.9kPa	9.6 (2.5–36.6)	0.001	4.3 (1.12–18.3)	0.001
		17-75kPa	59 (17.4–200)	<0.005	9 (2.49–32.2)
	Baseline lnHA		4.5 (3.4–5.9)	<0.005	2.8 (1.9–3.8)	<0.005
	Baseline age		1.07 (1.03–1.11)	<0.005	NS
	Male sex		1.59 (0.70–3.59)	0.262	NS
	Ever excessive alcohol use		0.8 (0.39–1.66)	0.556	NS
	Ever intravenous drug use		1.83 (0.87–3.84)	0.113	NS
	SVR		0.84 (0.25–2.83)	0.779	0.39 (0.1–1.35)	0.189

^aAnalysis of subpopulation of (560/591) patients with a baseline age above 30 years of age.

^b subpopulation (531/591) >30 years of age and no previous complications.

HR; Hazard ratio. lnHA; natural logarithm of bHA. NS; non-significant.