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. 2018 Jul 24;2:PO.18.00036. doi: 10.1200/PO.18.00036

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© 2018 by American Society of Clinical Oncology

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Fig 3. — The SPOP mutant prediction and its impacts on clinical and prognostic outcomes from retrospective (n = 1,626) and prospective GRID (n = 6,532) cohorts. (A) The pie chart of predicted molecular subclasses from the retrospective cohort with 1,626 samples, on the basis of the SCaPT (SubClass Predictor based on Transcriptional data) model and decision tree. Different colors represent molecular subclasses. (B) Associations between predicted SPOP mutant status and clinical variables via univariable analysis in the retrospective cohort, with SPOP wild type as reference. Box size indicates the significance from univariable analysis. (C) The pie chart of predicted molecular subclasses from the prospective GRID cohort with 6,532 samples, on the basis of the SCaPT model and decision tree. Different colors represent molecular subclasses. (D) Associations between predicted SPOP mutant status and clinical variables via univariable analysis in the prospective GRID cohort, with SPOP wild type as reference. Box size indicates the significance from univariable analysis. ERG, ERG-fusion position; ETS, other ETS fusion positive; OR, odds ratio; PSA, prostate-specific antigen.