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A: The combination of curcumin and resveratrol causes greater inhibition of growth of colon cancer p53 positive (wild type) and the p53-negative (p53−/−) HCT-116 cells and B: also stimulates apoptosis of HCT-116 (wt) cells than either agent alone. Each value represents mean ±SEM of 4 to 6 observations. *P < 0.025 or lower compared to control. Cur, curcumin; Resv, resveratrol.
