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Curcumin in combination with resveratrol causes A: a greater inhibition of HCT-116 (wt) colon cancer xenograft growth in SCID mice, B: is associated with decreased proliferation (mitotic index), C: increased apoptosis [TUNEL assay], and D: decreased NF-κB DNA binding activity. *P < 0.01 compared to control. Data in panel (A) for control and curcumin are similar to those recently published by our laboratory (39).
