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. 2018 Nov 27;20(3):261–271. doi: 10.1080/15384047.2018.1529091

Figure 3.

Figure 3.

TATDN1 acted as a molecular sponge for miR-451. (A-C) Expression of miR-451 in DDP-sensitive or DDP-tolerant NSCLC tissues and cell lines. (D) The predicted binding sequences between TATDN1 and miR-451, as well as the mutation of TATDN1. (E and F) Luciferase reporter assays in A549/DDP and H157/DDP cells after the co-transfection of established WT-TATDN1 or MUT-TATDN1 reporters and miR-control or miR-451 mimics. (G and H) TATDN1 knockdown activated while TATDN1 upregulation repressed the expression of miR-451 expression in DDP-resistant NSCLC cells. *P < 0.05.