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. 2018 Nov 27;20(3):261–271. doi: 10.1080/15384047.2018.1529091

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Figure 5. — Downexpression of TATDN1 decreased the survival and proliferation while promoted apoptosis of DDP-resistant NSCLC cells. (A-C) The mRNA expression of TRIM66 in NSCLC tissues and cell lines. (D-E) The protein expression of TRIM66 in NSCLC tissues and cell lines. (G-J) Survival rates and the proliferation of A549/DDP and H157/DDP cells were notably decreased with TRIM66 knockdown. (K and M) The apoptosis rates of A549/DDP and H157/DDP cells were markedly suppressed after the transfection of sh-TATDN1. (L and N) The protein expression of cleaved caspase-3 and Bcl-2 in A549/DDP and H157/DDP cells was detected by western blot.*P < 0.05.