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TATDN1 knockdown enhanced DDP-resistance of NSCLC through downregualtion of TRIM66 expression by sponging miR-451. (A and B) TATDN1 overexpression abolished miR-451-lowered TRIM66 mRNA expression, moreover, miR-451 knockdown reversed sh-TATDN1-repressed TRIM66 mRNA expression in A549/DDP and H157/DDP cells. (C and D) miR-451 inhibitor weakened sh-TATDN1-decreased TRIM66 protein expression in A549/DDP and H157/DDP cells. *P < 0.05.
