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The role of R-loops in transcription-associated DNA double-strand breaks.
The model for the role of R-loops in transcriptionally active genome protection. R-loops formed upon DNA double-strand break (DSB) induction recruit RAD52 and XPG. These factors process R-loops to initiate transcription-associated homologous recombination repair (TA-HRR). The TA-HRR mechanism is critical for the maintenance of genome stability in transcriptionally active regions.
