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. 2017 Aug;34(8):28–32.

Table 1.

Proposed Criteria for a Diagnosis of Neuropsychiatric Scurvy

For a diagnosis of neuropsychiatric scurvy, the patient must satisfy each of the following 3 criteria:

  1. The patient has either a or b:

    1. Psychomotor retardation plus evidence of an affective disturbance (either apathy, anxiety, or irritability);

    2. Extrapyramidal findings.

  2. The patient has some systemic evidence of hypovitaminosis C as manifested by either:

    1. Some disturbance of collagen metabolism, such as classic hemorrhagic findings or corkscrew hairs;

      or

    2. Biochemical evidence of deficiency, such as a low serum vitamin C level.

  3. The above findings respond to replacement of vitamin C.