Table 2.

Suspected Pathophysiologic Factors in Neuropsychiatric Scurvy

Vitamin C Actions	Result of Reduced Vitamin C Availability
Cofactor in catecholamine synthesis	Reduced production of catecholamines
Inhibits acetycholine release in rabbit caudate nucleus	Potential to disinhibit acetylcholine release and promote EPS
Regulates postsynaptic actions of GABA and glutamate	Loss of this regulatory factor may tend to promote EPS
Antioxidant	Loss of antioxidant activity may replicate the pathophysiology of Parkinson disease

Abbreviations: EPS, extrapyramidal symptoms; GABA, gamma-aminobutyric acid.