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. Author manuscript; available in PMC: 2019 Feb 11.
Published in final edited form as: Nat Immunol. 2018 Jun 20;19(7):659–664. doi: 10.1038/s41590-018-0128-9

Figure 1.

Figure 1.

Properties of mTECs and drivers of TSA-expression. A) Shown is a schematic of a cross section of the thymus. Highlighted are some of the unique and unusual features of mTECs that may help poise them for promoting display of TSA’s and the induction of tolerance. B) Shown is a single representative mTEC and an array of TSA’s being expressed. It now appears that Aire and Fezf2 are unique promoters of TSA expression in mTECs and that there are likely to be other factors beyond this transcriptional pair that drive this process.