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Inhibition of EcDHFR by diaminopyrroloquinazoline group of inhibitors. Top most panel shows the structure of the best hit with an aminophenyl methyl substitution. The central panel shows Lineweaver-Burk plots of the inhibitor titrated against substrate and cofactor (leftmost two panels) and slow-onset tight-binding mechanism (rightmost panel). The bottom most panel shows the kinetic scheme for the mechanism of inhibition. Adapted from20
