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Inhibition of EcDHFR by the diaminotriazine group of inhibitors. Top most panel shows the structure of the best hit. The central panel shows the Lineweaver-Burk plots of the inhibitor titrated against substrate and cofactor (leftmost two panels) and the docked pose of the small molecule inside the active site cavity of the enzyme (rightmost panel) (Adapted from24). The bottom most panel shows the kinetic scheme for the mechanism of inhibition. Adapted from20 .
