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. Author manuscript; available in PMC: 2020 Feb 18.
Published in final edited form as: Angew Chem Int Ed Engl. 2019 Jan 25;58(8):2371–2376. doi: 10.1002/anie.201813233

Table 3.

Aryl halide scope with a tetrasubstituted alkene.

graphic file with name nihms-1006456-t0006.jpg
[a]

0.1 mmol scale, isolated yield over 2 steps, reaction time 16 h. Esterification conditions unless otherwise noted: (COCl)2 (2 eq), DCM (0.1M); MeOH (excess)

[b]

Esterification conditions: DIC, DMAP, MeOH, DCM

[c]

12:1 ratio of isomers favoring the internal [d] Combined yield including deprotected product.