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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Pediatr Nephrol. 2018 Aug 11;34(9):1493–1500. doi: 10.1007/s00467-018-4031-2

Figure 2: Detection of CRELD2 in the urine from human ADTKD-UMOD patients.

Figure 2:

(A) Representative IF images of human renal biopsies obtained from patients with p.H177-R185del or p.W202S UMOD mutation and from normal kidneys, stained for CRELD2 (green) and uromodulin (red) with a nuclear counterstain (Hoechst 33342, blue). Scale bar: 40 μm. (B) Dot plot representation of urine CRELD2/Cr values measured by ELISA in 17 ADTKD-UMOD patients harboring various UMOD mutations, including H177-R185del, C106F, D172H, V93-G97delinsAASC, R178P and G103C, as well as in 7 genetically unaffected controls. Data represent mean ± SEM, *P<0.05 by t test. Figure 2 was originally published in JCI Insight [47].