Table 4.
Monthly Laboratory Values and Body Weights at Baseline, Mid-Study, and End-of-Study by Group†
| Intervention | Control | ANOVA P-Values | |||||||
|---|---|---|---|---|---|---|---|---|---|
| BL | Mid | End | BL | Mid | End | Group Effect |
Time Effect |
Inter- action Effect |
|
| Pre-Dialysis Weight (kg) | 87.2 ± 21.3 | 88.1 ± 21.5 | 87.4 ± 21.4 | 85.4 ± 21.7 | 85.4 ± 21.5 | 85.1 ± 21.5 | <0.0001* | 0.32 | 0.40 |
| Post-Dialysis Weight (kg) | 85.3 ± 21.3 | 85.6 ± 21.4 | 85.0 ± 20.6 | 83.0 ± 21.5 | 83.3 ± 21.6 | 82.8 ± 20.8 | <0.0001* | 0.34 | 0.99 |
| IDWG | 1.3 ± 2.0 | 2.2 ± 1.1 | 1.8 ± 1.1 | 1.4 ± 3.1 | 2.6 ± 1.4 | 2.4 ± 2.1 | 0.40 | 0.21 | 0.91 |
| Kt/V | 1.56 ± 0.28 | 1.48 ± 0.34 | 1.56 ± 0.34 | 1.64 ± 0.19 | 1.57 ± 0.28 | 1.55 ± 0.29 | 0.35 | 0.51 | 0.70 |
| Treatment duration (min) | 213 ± 48 | 210 ± 51 | 221 ± 31 | 225 ± 21 | 221 ± 22 | 231 ± 31 | 0.02* | 0.36 | 0.71 |
| Serum Albumin (g/dL) | 3.8 ± 0.3 | 3.8 ± 0.3 | 3.7 ± 0.3 | 3.9 ± 0.3 | 3.9 ± 0.2 | 3.8 ± 0.3 | 0.01* | 0.59 | 0.82 |
| Total Protein (g/dL) | 6.7 ± 0.5 | 6.8 ± 0.6 | 6.7 ± 0.6 | 6.8 ± 0.6 | 6.8 ± 0.6 | 6.7 ± 0.5 | 0.45 | 0.73 | 0.45 |
| Adjusted Calcium (mg/dL) | 9.1 ± 0.5 | 9.2 ± 0.8 | 9.3 ± 0.4 | 9.4 ± 0.8 | 9.4 ± 0.9 | 9.3 ± 0.6 | 0.017* | 0.88 | 0.76 |
| BUN (mg/dL) | 45 ± 14 | 44 ± 15 | 49 ± 16 | 61 ± 16 | 57 ± 17 | 59 ± 13 | <0.0001* | 0.54 | 0.32 |
| Carbon Dioxide (mEq/L) | 27 ± 2 | 25 ± 1 | 25 ± 1 | 25 ± 1 | 24 ± 2 | 25 ± 2 | 0.005* | 0.04* | 0.58 |
| Chloride (mEq/L) | 99 ± 2 | 98 ± 3 | 100 ± 2 | 99 ± 2 | 98 ± 3 | 98 ± 3 | 0.20 | 0.38 | 0.19 |
| Cr (mg/dL) | 6.7 ± 1.4 | 6.8 ± 1.5 | 6.8 ± 1.1 | 7.3 ± 3.1 | 6.9 ± 2.4 | 7.8 ± 4.4 | 0.014* | 0.27 | 0.23 |
| Iron Sat. (%) | 30 ± 13 | 28 ± 10 | 29 ± 10 | 27 ± 13 | 30 ± 15 | 30 ± 9 | 0.43 | 0.45 | 0.19 |
| nPCR (g/kg) | 0.92 ± 0.24 | 0.83 ± 0.21 | 0.94 ± 0.29 | 1.15 ± 0.29 | 1.08 ± 0.33 | 1.12 ± 0.25 | <0.0001* | 0.50 | 0.35 |
| Phosphate (mg/dL) | 5.0 ± 1.0 | 5.2 ± 0.4 | 5.2 ± 0.7 | 6.7 ± 1.9 | 6.4 ± 1.5 | 7.0 ± 1.7 | <0.0001* | 0.59 | 0.53 |
| K (mEq/L) | 4.4 ± 0.4 | 4.5 ± 0.4 | 4.6 ± 0.5 | 4.6 ± 0.6 | 4.7 ± 0.7 | 4.7 ± 0.4 | 0.07 | 0.82 | 0.887 |
| Sodium (mEq/L) | 139 ± 2 | 137 ± 3 | 138 ± 2 | 139 ± 2 | 138 ± 3 | 137 ± 3 | 0.635 | 0.047* | 0.233 |
| TIBC (mcg/dL) | 217 ± 23 | 224 ± 18 | 235 ± 25 | 237 ± 40 | 248 ± 36 | 245 ± 38 | <0.0001* | 0.007* | 0.44 |
| Total Iron (mcg/dL) | 65 ± 30 | 62 ± 19 | 66 ± 19 | 66 ± 38 | 74 ± 38 | 72 ± 24 | 0.01* | 0.14 | 0.234 |
†
Data are presented as mean ± SD. BL, baseline; BUN, blood urea nitrogen; Cr, creatinine; IDWG: intradialytic weight gain; K, potassium; MP, midpoint; nPCR, normalized protein catabolic rate; N/A: not available; PO4, phosphate; TIBC, total iron binding capacity.
*
P < 0.05.