Fig. 3.

CHARMED-FR reductions in multiple sclerosis normal appearing white matter excluding perilesional tissue.

Example of the lesion mask expansion by one and two voxels (panel A). Right: Results (highlighted in blue) in which TBSS found a significant reduction of the FR in multiple sclerosis NAWM compared to healthy controls for the original lesion masks (panel B), for the masks expanded by one voxel (panel C, volumetric overlap of regions with significant differences as compared to analysis b: 98%), and for the masks expanded by two voxels (panel D, volumetric overlap of regions with significant differences as compared to analysis b: 96%), are shown.

Abbreviations: FR = restricted fraction; NAWM = normal-appearing white matter; TBSS = Tract Based Spatial Statistics.