Fig. 4.

Restricted fraction in periventricular area.

Example of the ventricle mask as well as surrounding concentric periventricular masks (overlaid on fractional anisotropy map) at perpendicular distances from the ventricles ranging from 1 to 6 voxels (panel a). Panel b shows box[HYPHEN]whisker plots of restricted fraction values in each layer (distance from ventricles: from 2 to 6 voxels; the first layer was excluded in order to minimize cerebrospinal fluid contamination). Boxes represent quartiles, whiskers represent extremes, crosses represent outliers. Repeated measures analysis of variance found an effect of both group (p<0.001) and distance (p<0.001), but not of group*distance interaction (p=0.78).