Fig. 5.

Asymmetry index in MS vs NAWM.

Box-whisker plots depicting the asymmetry index NIA between MS lesions and contralateral NAWM (1: maximum asymmetry towards the lesion, −1: maximum asymmetry towards contralateral NAWM or healthy controls) across patients. Red: positive NIA (** = p < .01, Bonferroni corrected). Blue: negative NIA (** = p < .01, Bonferroni corrected). Boxes represent quartiles, whiskers represent extremes, dots represent outliers.

Abbreviations: FR = restricted fraction; NAWM = normal-appearing white matter; NIA = normalized index of asymmetry