1. Comparisons in included studies.
Intervention | Control (no NAC) | Reference |
NAC 600 mg orally twice daily plus amoxicillin 1000 mg twice daily, omeprazole 20 mg twice daily and clarithromycin 500 mg twice daily | Same regimen, placebo controlled | Hamidian 2015 |
NAC 600 mg orally twice daily plus amoxicillin 500 mg four times daily, bismuth citrate 120 mg four times daily, omeprazole 20 mg twice daily, and clarithromycin 500 mg twice daily | Same regimen, without placebo | Emami 2014 |
NAC 400 mg orally twice daily plus sequential therapy with rabeprazole 20 mg and amoxicillin 1g (both twice daily) for the first five days, followed by rabeprazole 20 mg, clarithromycin 500 mg and metronidazole 500 mg (all drugs twice daily) for the remaining five days | Same regimen, without placebo | Yoon 2014 |
NAC 600 mg orally twice daily plus ciprofloxacin 500 mg twice daily, pantoprazole 40 mg twice daily and bismuth subcitrate 120 mg two tablets twice daily | Same regimen, placebo controlled | Karbasi 2013 |
NAC 600 mg orally once a day for one week before a culture‐guided regimen, including a proton pump inhibitor (PPI) plus two antibiotics | Same regimen, without placebo | Cammarota 2009 |
NAC 400 mg orally three times a day plus clarithromycin 500 mg twice daily and lansoprazole 30 mg twice daily | Same regimen, without placebo | Gurbuz 2005 |
NAC 600 mg orally twice daily plus omeprazole 40 mg twice daily and amoxicillin 750 mg twice daily | Same regimen, without placebo | Zala 1994 |
NAC 600 mg orally three times a day plus amoxicillin 375 mg three times a day | Same regimen, placebo controlled | Hansen 1994 |
NAC: N‐acetylcysteine