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. Author manuscript; available in PMC: 2019 Aug 20.
Published in final edited form as: ChemMedChem. 2018 Jul 11;13(16):1681–1694. doi: 10.1002/cmdc.201800188

Table 1.

Structures and inhibitory activities of pyrazolopyrimidinone WEE1 inhibitors.

graphic file with name nihms-1516457-t0008.jpg

Inhibitory activity for the synthesized compounds from a recombinant WEE1 TR-FRET binding assay are given as the half maximal inhibitory concentration (IC50) in nm.