Table 2.
Baseline characteristics of responders and non-responders to Switzerland hemagglutinin antigen.
|
NoR
n = 20 |
R
n = 15 |
p-value* | |
|---|---|---|---|
| CHARACTERISTICS AT TIME OF TRANSPLANTATION | |||
| Recipient | |||
| Age at transplantation (years) | 53 ± 13 | 51 ± 16 | 0.74 |
| Origin of renal disease, n (%) | 0.80 | ||
| Glomerulonephritis | 1 (5) | 3 (20) | |
| Diabetes mellitus | 3 (15) | 2 (13) | |
| Vascular | 6 (30) | 4 (27) | |
| Genetic | 4 (20) | 3 (20) | |
| Uropathy | 1 (5) | 1 (7) | |
| Undetermined | 5 (25) | 2 (13) | |
| Duration of dialysis (months) | 21 ± 20 | 31 ± 43 | 0.83 |
| DONOR | |||
| Donor age (years) | 50 ± 14 | 48 ± 17 | 0.71 |
| Donor sex, men, n (%) | 14 (70) | 11 (73) | 1.0 |
| Deceased donor, n (%) | 17 (85) | 14 (93) | 0.69 |
| Extended criteria donor, n (%) | 6 (30) | 7 (47) | 0.48 |
| TRANSPLANTATION | |||
| Number of HLA-A, B, C, DR, DQ mismatches | 6.1 ± 1.5 | 5.2 ± 1.9 | 0.17 |
| Combined kidney-pancreas transplantation, n (%) | 2 (10) | 1 (7) | 1.00 |
| Cold ischemia time (min) | 677 ± 414 | 806 ± 490 | 0.40 |
| Delayed graft function, n (%) | 0 (0) | 3 (21) | 0.06 |
| CHARACTERISTICS AT TIME OF VACCINATION | |||
| Time elapsed since transplantation (months) | 23 ± 19 | 24 ± 15 | 0.77 |
| IMMUNOSUPPRESSION | |||
| Induction therapy | |||
| Thymoglobuline, n (%) | 17 (85) | 9 (60) | 0.12 |
| Maintenance regimen | |||
| Tacrolimus, n (%) | 19 (95) | 10 (67) | 0.06 |
| Ciclosporin, n (%) | 1 (5) | 5 (33) | |
| mTOR-Inhibitors, n (%) | 2 (10) | 1 (7) | 1.00 |
| Mycophenolate, n (%) | 18 (90) | 14 (93) | 1.00 |
| Azathioprin, n (%) | 1 (5) | 0 | |
| Prednisone, n (%) | 12 (60) | 12 (80) | 0.28 |
| GRAFT FUNCTION | |||
| eGFR (ml/min/m2) | 59 ± 22 | 61 ± 23 | 0.78 |
| Proteinuria**, n (%) | 3 (15) | 3 (20) | 1.00 |
Unpaired t-test was used for comparison of continuous variables and Fisher's exact test was used for comparison of proportions.
Proteinuria is defined as >0.5 g/24 h or >40 mg/mmol creatinine in spot-urine.
mTOR, mammalian target of rapamycin; eGFR, estimated glomerular filtration rate.