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. 2019 Feb 5;10:97. doi: 10.3389/fimmu.2019.00097

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Copyright © 2019 Papadaki, Rinotas, Violitzi, Thireou, Panayotou, Samiotaki and Douni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synergistic effect of RANKL and TNF in inflamed bone loss. MicroCT analysis in the trabecular region of the calcaneous bone from mice of each group at 6 weeks of age as shown by (A) representative longitudinal sections and (B) cross-sectional sections. Quantitative measurements with microCT in the trabecular area of the calcaneous bone for BV/TV (Bone Volume/Total Volume, %), and Tb.N (Trabecular Number per mm) in (C) Tg197/Tg5519 and littermates (n = 8–10, equal number of sexes per genotype), and (D) Tg197/Tg5516 and littermates (n = 8, equal number of sexes per genotype). Data represent mean values ± SEM. One-Way ANOVA and Tukey post-hoc test was performed for more than two groups. Asterisks mark statistically significant difference (^*p < 0.05, ^**p < 0.01, ^***p < 0.001).