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. 2019 Feb 5;10:153. doi: 10.3389/fimmu.2019.00153

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Copyright © 2019 Maekawa, Wang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathway map of Notch signaling (A) and Th1 differentiation (B) in KEGG. In each gene boxes, the gene expression levels are shown in 4 fish (C, Carp; G, Grouper; L, Largemouth bass; M, Mullet) spleen 1 day after infection with A. sobria, V. harveyi, N. seriolae, and L. garvieae, respectively, when compared to the control group. The lower expression levels of genes are shown in green, and the higher expression levels of genes are shown in red. Undetected genes are shown by white coloring (see color legend in figure).