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. 2019 Feb 5;10:65. doi: 10.3389/fneur.2019.00065

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Copyright © 2019 Ling, Wang, Sun, Zhao and Ni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Behavior in the open field. Exploratory activity is reflected by the score of horizontal activity (A), vertical activity (B) and the sum of them (locomotor activity) (C). Anxiety-like behavior is reflected by delay time (D) and grooming times (E). ^*P < 0.05, compared with ND,^#P < 0.05, compared with KOD (n = 18/group).