Table 2.
Summary results of the genome-wide association studies of asthma treatment response.
| Treatment | SNP | Chr. regiona | Positionb | Nearest gene(s) | Effect allele | Betac, d | p-valued | References |
|---|---|---|---|---|---|---|---|---|
| SABA | rs73650726 | 9q21 | 85152666 | SPATA31D1-RASEFe | A | −3.80 | 7.69 × 10−9 | (36) |
| rs7903366 | 10q21 | 53689774 | PRKG1 | T | 1.23 | 3.94 × 10−8 | ||
| rs7081864 | 10q21 | 53690331 | PRKG1 | A | 1.23 | 4.94 × 10−8 | ||
| rs7070958 | 10q21 | 53691116 | PRKG1 | A | −1.24 | 4.09 × 10−8 | ||
| Mepolizumab | rs114633080 | 6q24 | 145404255 | IFNA14-IFNA22Pe | NA | NA | NA | (39) |
| rs137893217 | 6q24 | 145427162 | IFNA14-IFNA22Pe | NA | NA | NA | ||
| rs78517277 | 6q24 | 145465077 | IFNA14-IFNA22Pe | NA | NA | NA | ||
| rs117220641 | 6q24 | 145496192 | IFNA14-IFNA22Pe | NA | NA | NA | ||
| rs10811516 | 9p21 | 21255049 | IFNA14-IFNA22Pe | NA | NA | NA | ||
| rs10811517 | 9p21 | 21256306 | IFNA14-IFNA22Pe | NA | NA | NA |
a
Chromosomal region.
b
Positions based on GRCh37/hg19 build.
c
Beta values for the effect alleles.
d
Association results of the meta-analysis.
e
Novel locus (no previous evidence of association with asthma). NA: not available.