Table 4.

Novel loci of asthma and allergic diseases revealed by meta-analyses published between 2016 and 2018.

Phenotypes	SNP	Chr. regiona	Positionb	Nearest gene (s)	Effect allele	ORc, d	p-valued	References
Asthma/hay fever/eczema/rhinitis	rs12743520	1p22	93037112	PIGX	C	0.93e	3.83 × 10−8e	(49)
	rs61815704	1q21	152893891	IVL-SPRR2E	C	1.14e	5.16 × 10−9e
	rs1214598	1q24	167426424	RP11-104L21.2	G	0.95e	5.14 × 10−11e
	rs4916533	3q29	196373582	LRRC33	C	0.93e	1.66 × 10−8e
	rs56267605	4q27	123363109	ADAD1-IL2	A	1.05e	2.56 × 10−12e
	rs6461503	7p21	20560996	ABCB5	C	1.05e	3.19 × 10−10e
	rs2169282	9p24	6350235	TPD52L3	G	1.09e	1.80 × 10−10e
	rs12413578	10p14	9049253	SLC7A10	C	0.91e	1.09 × 10−14e
	rs10876864	12q13	56401085	SUOX	A	1.05e	1.41 × 10−13e
	rs9911533	17q21	38775476	SMARCE1	T	0.92e	9.70 × 10−16e
	rs10414065	19q13	33721455	SLC7A10-CEBPA	C	0.91e	2.63 × 10−10e
	rs2766664	20q13	52171241	RP4-724E16.2	G	1.08e	8.07 × 10−11e
	rs10033073	1p36	4775401	EVI5	G	1.04	1.20 × 10−10
Asthma/hay fever/eczema	rs1057258	1p36	234115629	INPP5D	C	1.05	1.40 × 10−10	(45)
	rs10414065	1q21	33721455	SLC7A10-CEBPA	C	1.10	6.10 × 10−18
	rs10663129	1q21	141321836	RASA2	ACT	1.04	1.10 × 10−13
	rs10760123	1q42	123650534	PHF19-TRAF1	T	1.03	5.20 × 10−9
	rs10910095	2p25	2510755	TNFRSF14-FAM213B	G	1.04	2.70 × 10−8
	rs11169225	2q12	50345671	AQP2	A	1.05	1.20 × 10−11
	rs12440045	3q28	41782684	RTF1-ITPKA	C	1.03	4.90 × 10−10
	rs13088318	3q29	101242751	FAM172BP-TRMT10C	A	1.03	8.60 × 10−9
	rs13153019	4p16	176782218	LMAN2-RGS14	C	1.04	1.30 × 10−8
	rs13403656	4q24	112269127	BCL2L11-ANAPC1	A	1.05	2.20 × 10−8
	rs13384448	4q27	228707862	CCL20-DAW1	T	1.04	2.80 × 10−12
	rs227275	5p13	103593898	MANBA	C	1.03	3.70 × 10−11
	rs17664743	5q22	50253897	C7orf72-IKZF1	A	1.04	6.20 × 10−11
	rs250308	5q31	118684297	TNFAIP8	T	1.03	4.00 × 10−9
	rs2910162	6p21	159909345	MIR3142-MIR146A	G	1.03	2.50 × 10−9
	rs35469349	7p12	128294709	PTPRK	A	1.04	2.30 × 10−10
	rs3540	7p21	91045408	IQGAP1	G	1.04	3.30 × 10−11
	rs4296977	8q21	77018542	GSAP	C	1.06	2.10 × 10−13
	rs4801001	9p24	52336175	DYNAP-RAB27B	T	1.03	5.90 × 10−9
	rs4574025	9q33	60009814	TNFRSF11A	T	1.03	6.80 × 10−9
	rs4671601	9q34	64836267	LOC339807	C	1.04	8.80 × 10−9
	rs4943794	10p14	41173408	FOXO1	C	1.04	7.20 × 10−12
	rs5758343	10p14	41816652	TEF-TOB2	A	1.05	4.80 × 10−14
	rs55726902	10p14	48196982	HDAC7	G	1.05	2.60 × 10−16
	rs4848612	10q24	112388538	BCL2L11-ANAPC1	A	1.04	2.30 × 10−10
	rs61192126	11q13	72394852	LINC00870-RYBP	T	1.04	8.90 × 10−11
	rs59593577	11q13	95425526	SESN3-FAM76B	C	1.05	1.60 × 10−11
	rs6489785	12q13	121363724	SPPL3-HNF1A-AS1	T	1.04	1.60 × 10−15
	rs6977955	12q24	28156887	JAZF1	T	1.05	7.10 × 10−13
	rs697852	12q24	226914734	ITPKB	A	1.04	1.60 × 10−9
	rs7130753	13q22	111470567	LAYN-SIK2	C	1.05	7.00 × 10−15
	rs71368508	14q13	4521473	SMTNL2-ALOX15	C	1.12	2.00 × 10−9
	rs7137828	14q21	111932800	ATXN2	T	1.03	2.20 × 10−10
	rs7207591	14q24	40414862	STAT5B	A	1.04	1.40 × 10−9
	rs72033857	14q24	167390671	RNASET2-MIR3939	C	1.06	1.20 × 10−9
	rs7214661	14q32	43430696	MAP3K14-ARHGAP27	G	1.03	1.20 × 10−8
	rs73205303	15q15	36467830	RUNX1	A	1.04	7.90 × 10−10
	rs74847330	15q22	143831599	KYNU-ARHGAP15	A	1.05	1.80 × 10−9
	rs75557865	16p13	121652141	SLC15A2	G	1.03	1.60 × 10−8
	rs76167968	17q21	35681738	SFPQ-ZMYM4	T	1.06	1.30 × 10−8
	rs76081789	17q21	44846426	SIK1	T	1.07	1.30 × 10−8
	rs9323612	20q13	75968608	JDP2-BATF	A	1.03	8.60 × 10−9
	rs9372120	20q13	106667535	ATG5	G	1.04	4.20 × 10−11
	rs9383820	20q13	157419508	ARID1B	C	1.04	1.20 × 10−8
	rs9573092	21q22	73627275	PIBF1-KLF5	A	1.03	2.70 × 10−8
	rs9989163	22q13	103235012	RCOR1-TRAF3	A	1.03	1.90 × 10−8

^aChromosomal region.

^bPositions based on GRCh37/hg19 build.

^cOdds ratio for the effect alleles.

^dAssociation results of the meta-analysis.

^eAssociation results of the discovery phase.