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. 2019 Feb 11;9:1733. doi: 10.1038/s41598-018-38271-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Early plateau fibrils are in thermodynamic equilibrium with structurally disordered species. (A) Averaged CD spectra of early (top) and late (bottom) phases of the plateau at 37 °C (red, solid), 10 °C (blue, solid) and again at 37 °C (red, dashed). (B) The [θ]_{198/220 nm} ratio ± standard deviation of the ellipticities from individual frames during cooling (37-30-25-20-15-10 °C) and heating (10-15-20-25-30-37 °C) cycles of early plateau (top) and late plateau (bottom) samples have been calculated and plotted as function of time with colors ranging from red to light blue.