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. 2019 Feb 11;9:1733. doi: 10.1038/s41598-018-38271-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Structurally disordered species originating from early plateau fibrils interact with the plasma membranes. (A) CLSM images of membrane sheets incubated with early (green panel) or late plateau fibrils (red panel) immediately after extraction at 37 °C, after 6 h. incubation at 4 °C with or without subsequent incubation at 37 °C for 6 h. In addition we show sheets incubated with monomeric αSN prior to fibrillation (black panel) and a control without αSN (grey panel). Scale bars are 10 um (B) The quantified membrane binding (means ± s.e.m., n = 20) normalized to the binding before fibrillation (two-way ANOVA, Tukey Test; ****P < 0.0001, ns = non-significant). Inset shows the normalized membrane binding as function of the residual concentration of the supernatant.