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Genomic analysis of IMiDs-resistant HMCL
| HMCLs | aCGH | Targeted DNA sequencing |
|---|---|---|
| MM.1S parental | 1 copy CRBN on a 2N karyotype | Negative |
| MM.1SLenRes | 1 copy CRBN on a 2N karyotype | CRBN Mutation |
| SNV: Ser 271 Phe (24%) | ||
| Truncation: Trp399 (8%) | ||
| Splice mutation (24%) | ||
| KMS11 parental | 1 copy CRBN on a 2N karyotype (subclonal), 3 copy on a 4N karyotype | Negative |
| KMS11LenRes | 0 copy CRBN on a 2N karyotype (subclonal), 1 copy on a 4N karyotype | Negative |
