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. 2019 Feb 11;9:1729. doi: 10.1038/s41598-018-38408-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dysregulated expression of cell surface marker expression by Cbfb-MYH11. (A) Schematic representation of experimental design. Cbfb^+/56M; Mx1-Cre⁺ or Cbfb^+/+; Mx1-Cre⁺ mice were injected with polyinosinic-polycytidylic acid (pIpC) to induce the expression of Cbfb-MYH11. Bone marrow cells were harvested, lineage negative (lin⁻) cells isolated, and stained with antibodies for IL1RL1 and CSF2RB. (B) Representative FACS plots showing the expression of CSF2RB and IL1RL1 at the indicated time points after the induction of Cbfb-MYH11. (C) Bar graph showing the percentages (%) of CSF2RB⁻ IL1RL1⁺ (left) and CSF2RB⁺ IL1RL1⁺ (right) cells at the indicated time points. (D) Representative IL1RL1 and KIT staining of CSF2RB⁻ cells from leukemic Cbfb-MYH11^+/56M, Mx1-Cre⁺ mice. (E) Bar graph of IL1RL1 and KIT expression in CSF2RB⁻ population. N ≥ 3; **P < 0.01; ****P < 0.0001.