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. 2019 Feb 11;9:1782. doi: 10.1038/s41598-018-38466-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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APS protected MEFs against H₂O₂-induced cell damage. MEFs were stimulated with 250 μM H₂O₂ for 12 h, and then incubated with different APS concentrations (0–30 µg/mL). (A) Cell proliferation was then measured using the MTT method. (B,C) The T-AOC and SOD activity in the cells were analyzed at 450 nm. (D,E) The concentrations of IL-6 and IL-8 were detected by ELISA. The values represent the mean ± SD (n = 3 per group); **P < 0.01 and ***P < 0.001.