Fig. 2. Luteolin, quercetin or myricetin ameliorates skin fibrosis and excessive collagen deposition in vivo.

a Representative images of fibrosing skin tissue in bleomycin-induced skin fibrosis model from DMSO-treated mice and drug-treated mice after hematoxylin and eosin (H&E), Masson’s trichrome and Picrosirius red staining. b Quantitative analysis of dermal thickness and collagen density of fibrosing skin from vehicle-treated mice and drug-treated mice in bleomycin-induced skin fibrosis model. c Representative images of macroscopy, H&E and Picrosirius red staining of hypertrophic scar (HS) tissue in mechanical load-induced HS model from DMSO-treated mice and drug-treated mice. d Quantitative study of gross scar, cross-section area, and collagen density of HS tissue from DMSO-treated mice and drug-treated mice in HS model. Data are the mean ± SD (three independent experiments); *P < 0.05, **P < 0.01, ***P < 0.001