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. 2019 Feb 11;10(2):124. doi: 10.1038/s41419-019-1333-7

Fig. 3. Luteolin, quercetin or myricetin inhibits fibroblast proliferation in vivo and in vitro.

Fig. 3

Representative images of hypertrophic scar (HS) in a fibrosing skin in bleomycin-induced model and b mechanical load-induced HS model from DMSO-treated mice and drug-treated mice stained for proliferating cell nuclear antigen (PCNA) and quantitative analysis of PCNA-positive cells. c Representative immunofluorescence images and quantitative results of EdU incorporation assay in human dermal fibroblasts (HDFs). EdU is shown by red fluorescence and nucleus by blue fluorescence. d Representative images and quantitative results of colony formation assay exhibit an evidently reduced number of HDF colony (purple) after drug treatment. Data are the mean ± SD (three independent experiments); *P< 0.05, ***P< 0.001