Fig. 6. 5, 7, 3′, 4′ hydroxyl-containing flavones selectively bind to activin receptor-like kinase 5 (ALK5).

a Schematic of computational docking simulation of 5, 7, 3′, 4′-hydroxylated flavones interaction with the ATP-binding site of ALK5. Amino acid residues interacting with the compounds are shown (yellow) with the hydrogen bonds indicated by dashed lines. b Mean docking score of 5, 7, 3′, 4′ hydroxyl-containing flavones vs. flavones with other structures. c Docking simulation of luteolin, quercetin, and myricetin binding to the catalytic site of ALK5. Amino acid residues interacting with the compounds are indicated and hydrogen bonds are represented with straight dashed lines. **P < 0.01