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. 2019 Feb 11;10(2):118. doi: 10.1038/s41419-019-1383-x

Fig. 8. Combination of IVM, CQ and TRAIL suppresses tumor growth in vivo.

Fig. 8

a Log-transformed tumor volume curves of U87 xenografts in mice treated with IVM (1.5 mg/kg, intraperitoneal injection, daily, from day 0 to 8), CQ (50 mg/kg, intraperitoneal injection, daily, from day 0 to 8), TRAIL (100 μg, intraperitoneal injection, daily, from day 1 to 8), their solvents or indicated combination (n = 7 except IVM + CQ + TRAIL group is n = 8, mean ± SEM). b, c Tumor volume curves (b) and body weight curves (c) of treated U87 xenografts (mean ± SEM). *P < 0.05 compared with vehicle group. d Western blot analysis of U87 xenografts isolated from mice treated as indicated. GAPDH was used as the loading control. e Quantification of grayscale ratio of cleaved caspase-8 or cleaved caspase-3 to GAPDH in d by Photoshop software. The line represent the mean value. f Schematic overview of the purposed pathway for the combination of KPNB1 inhibitor, TRAIL and lysosome inhibitor based on the results of this study