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. 2019 Feb 11;9:80. doi: 10.1038/s41398-019-0416-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Schematic overview of the study: validation of [¹¹C]DASB-PET using groups of Slc6a4^+/+, Slc6a4^+/−, and Slc6a4^−/− mice (part A) and investigation of the effects of a chronic CORT paradigm on SERT density as measured by [¹¹C]DASB-PET and western blot, as well as depression-like behavior (part B). [¹¹C]DASB [¹¹C]-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile, PET positron emission tomography, Slc6a4/SERT serotonin transporter, NSF novelty-suppressed feeding test, CORT corticosterone treatment, CTRL control/vehicle treatment