Fig. 2. BP_nd values for CORT-treated and control groups.

a Definition of brain ROIs (hippocampus—purple; striatum—red; thalamus—green; cortex—blue; cerebellum—yellow) for subregional analysis of SERT density on representative coronal and horizontal MR and MR co-registered PET summation images (0–90 min). BP_nd values at baseline and after treatment with corticosterone (CORT group) or vehicle (CTRL group) in b hippocampus, c striatum, d thalamus, and e cortex of wild-type mice. Black dotted line indicates mean BP_nd value of baseline scans, red dotted line indicates mean BP_nd value of second scan in CORT group, and blue dotted line indicates mean BP_nd value of second scan in CRTL group. One-way analysis of variance indicated a significant change in baseline BP_nd values following CORT treatment in hippocampus (F_2,52 = 12.58, P < 0.0001), striatum (F_2,52 = 16.82, P < 0.0001), thalamus (F_2,52 = 20.51, P < 0.0001), and cortex (F_2,52 = 10.03, P = 0.0002), n = 8–27. P values indicate results of post hoc Tukey’s multiple comparison analysis. Data are presented as paired individual values (gray lines) at baseline and after CORT or CTRL treatment. BP_nd non-displaceable binding potential, SUV standardized uptake value, ROI region of interest, CORT corticosterone treatment, CTRL control/vehicle treatment, ns nonsignificant, MR magnetic resonance, PET positron emission tomography