Table 1.
Overview of examined animals, groups, and numbers investigated with [11C]DASB-PET
| Genotype | Number/sex | Body weight (g) | Injected activity (MBq) | Molar activitya (GBq/µmol) | Injected dose (nmol/kg) |
|---|---|---|---|---|---|
| Part A | |||||
| Wild type (Slc6a4+/+) | 8/male | 24.9 ± 2.3 | 22.5 ± 18.8 | 210.6 ± 101.3 | 3.9 ± 2.6 |
| 5/female | 22.1 ± 2.3 | 40.4 ± 3.7 | 240.2 ± 173.5 | 12.6 ± 9.6 | |
| Slc6a4 +/– | 5/male | 25.8 ± 2.3 | 34.5 ± 5.1 | 331.4 ± 97.5 | 4.4 ± 1.5 |
| 5/female | 19.5 ± 1.5 | 37.6 ± 5.8 | 271.7 ± 96.4 | 7.8 ± 2.5 | |
| Slc6a4 −/– | 5/male | 25.7 ± 4.1 | 33.6 ± 4.7 | 261.0 ± 183.8 | 7.3 ± 4.1 |
| 4/female | 19.0 ± 1.8 | 35.5 ± 4.1 | 333.2 ± 331.7 | 10.3 ± 6.7 | |
| Wild type (Slc6a4+/+) | 4/male | 27.2 ± 1.2 | 29.0 ± 3.2 | 48.9 ± 10.4 | 152.8 ± 12.1 |
| low molar activity | |||||
| Part B | |||||
| Wild type | |||||
| Baseline PET | 28/male | 23.8 ± 1.1 | 6.2 ± 1.6 | 73.2 ± 13.5 | 3.8 ± 1.7 |
| Post-treatment PET | |||||
| CORT | 20/male | 28.9 ± 1.6 | 5.64 ± 0.91 | 75.5 ± 26.3 | 2.94 ± 1.20 |
| CTRL | 8/male | 29.7 ± 2.3 | 5.24 ± 0.58 | 57.1 ± 14.6 | 3.34 ± 1.25 |
Slc6a4 gene encoding for the serotonin transporter, CORT corticosterone treatment, CTRL control/vehicle treatment
aAt the time of radiotracer injection into the animals