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. 2019 Feb 12;5:11. doi: 10.1038/s41421-018-0074-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–c Genes with more significant expression modulation than average (absolute values of expression changes of all genes) were selected. The overlapping genes between the sh-Dnmt1 and Tet1 over-expressed groups were identified (a). In addition, the correlation between the expression changes induced by sh-Dnmt1 and Tet1 were listed in b. Consistently up-regulated or down-regulated genes were summarized in c by overlapping the results shown in a. d Tet1-induced and sh-Dnmt1-induced effects on DNA demethylation, gene expression, and reprogramming were compared. e Correlations between demethylation and expression changes were determined in different groups. f, g The demethylation (f) and expression changes (g) between the consistently demethylated 1680 genes identified in Fig. 1g and all genes were compared