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. 2019 Feb 12;5:11. doi: 10.1038/s41421-018-0074-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, b The genes were divided as described in Fig. 5a. The differences in demethylation (a) and gene expression changes (b) induced by Tet1 were compared between the two reprogramming systems. c, d In total, 606 genes were selected (see text). Tet1 induced larger demethylation on these genes in the presence of Vc than in the absence of Vc. The expression of these genes decreased during reprogramming but could be reversed by Tet1 in the presence of Vc. Demethylation (c) and gene expression changes (d) were summarized. e, f In total, 32 genes that undergo significant down-regulation were selected for analysis (e). Of these 32 genes, the expression changes of 15 mesenchymal genes were determined by qPCR (f)