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. 2019 Feb 11;9:1744. doi: 10.1038/s41598-018-38372-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes of the brain’s dynamical coupling structure prior to and after epileptic seizures. Enlarged views of exemplary similarity matrices ξ covering a period of 24 h from two subjects with epilepsy. Seizure onsets are marked by bolts on top and to the right of each matrix. Seizures lasted for about 2 min, on average. For a given coupling structure–represented as a point on the matrix diagonal–, the similarity to coupling structures at previous times can be found on the vertical line above this point, or on the horizontal line to the left of this point. Dark shading (small values of ξ) denotes similar coupling structures and light shading (high values of ξ) denotes dissimilar coupling structures.