Fig. 6. Fli-1 inhibiting compounds suppress leukemic cell growth in vitro and in vivo.

a, b Fli-1 knockdown via shRNA in Daudi cells (a) resulted in significant upregulation of miR145 expression (b). c Both A661 and A665 inhibit leukemogenesis in a mouse model of leukemia in which Fli-1 is induced by retroviral insertional mutagenesis. Newborn BALB/c mice (n = 7 per group) were infected with F-MuLV and 6 weeks later treated with A661 or A665 (3 mg/kg) every other day for a total of six injections. Latency to death was used to plot a Kaplan-Meier survival curve (d, e). Spleen weights (d) and hematocrit values (e) of leukemic mice at time of scarification