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. 2019 Feb 11;10:705. doi: 10.1038/s41467-019-08584-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Ripk1^−/−Ripk3^−/−Tradd^+/− mice succumb to lethal TNFα-induced shock. a Body temperatures of mice of indicated genotypes over time. t tests show a significant difference in body temperature between Ripk1^−/−Ripk3^−/−Tradd^+/− and Ripk1^−/−Ripk3^−/−Tradd^−/− mice at 2 h and 4 h after injection. Graph presented as mean ± SEM. *p < 0.05 as determined by Student’s t test. b Kaplan–Meier plot showing survival of mice of indicated genotypes. Logrank test shows a significant difference in survival between Ripk1^−/−Ripk3^−/−Tradd^+/− and Ripk1^−/−Ripk3^−/−Tradd^−/− mice (p = 0.0069)