Fig. 3. Disc1 svΔ2 in female rats also demonstrates deficits in white matter microstructural integrity and contributes to global alterations inneurite density.

a Whole-brain voxel-wise tract-based spatial statistics reveal significant areas of decreased FA in female Disc1 svΔ2 rats (n = 6) compared to female controls (n = 6) (voxels in yellow). Eight representative coronal sections (left [anterior] to right [posterior]) and single representative axial and sagittal sections reveal significant regions of decreased FA identified in the left inferior neocortex, external capsule, corpus callosum, and internal capsule. b Disc1 svΔ2 female rats demonstrated significant areas of decreased NDI compared to female controls (voxels in cyan). Eight representative coronal sections (left [anterior] to right [posterior]) and single representative axial and sagittal sections show significant regions of decreased NDI in the right superior neocortex, external capsule, corpus callosum, and right internal capsule. c Disc1 svΔ2 female rats did not demonstrate significant differences in ODI compared to female controls